In these cases treatment failure withdrawals, adverse effects additional antibiotics and general practitioner visits were required 3 times more often and the cost of additional medication for treating failure or adverse effects was 3 times higher for patients treated with cefaclor than for patients receiving roxithromycin.
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In a placebo-controlled study 95 subjects with allergic rhinitis , there was no evidence of an effect of astelin nasal spray 2 sprays per nostril twice daily for 56 days on cardiac repolarization as represented by the corrected qt interval qtc of the electrocardiogram.
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These include colchicine toxicity with colchicine; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; and hypotension with calcium channel blockers metabolized by cyp3a4 e.